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Abortive initiation, also known as abortive transcription, is an early process of genetic transcription in which RNA polymerase binds to a DNA promoter and enters into cycles of synthesis of short mRNA transcripts which are released before the transcription complex leaves the promotor. This process occurs in both eukaryotes and prokaryotes. Abortive initiation is typically studied in the T3 and T7 RNA polymerases in bacteriophages, and in ''E. coli''. ==Overall process== Abortive initiation occurs prior to promoter clearance. # RNA polymerase binds to promoter DNA to form an RNA polymerase-promoter ''closed'' complex # RNA polymerase then unwinds one turn of DNA surrounding the transcription start site to yield an RNA polymerase-promoter ''open'' complex # RNA polymerase enters into abortive cycles of synthesis and releases short RNA products (up to 10 nucleotides in length) # RNA polymerase escapes the promoter and enters into the elongation step of transcription 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Abortive initiation」の詳細全文を読む スポンサード リンク
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